生命的创造与延续——从基础科学到应用科学Creation and Continuation of Life: from Basic Science to Applied Science
周琪;
摘要(Abstract):
生命科学旨在探索和揭示生命本质,运用多种生物技术造福人类。受限于早期生物科学和技术发展水平,人们难于一窥生命的起源、发育和遗传奥秘的全貌。经过长达百年的知识累积和技术进步,工程学理念逐渐被引入现代生物学中,人们对于生命本质的理解日趋深入,并逐步具备改造甚至创造生命的能力。生物技术的发展和应用拓宽了工程科学的疆域,工程科学的宽阔视野和方法则促进基础科学与生物技术的发展,二者相辅相成,逐渐在当代为造福人类提供了强有力的手段。结合干细胞与再生医学领域的创新实践和最新研究进展,探讨了生命科学领域中基础研究、生物技术与工程科学结合路径的设计与发展前景。
关键词(KeyWords): 生命科学;生物工程;干细胞与再生医学;工程科学
基金项目(Foundation):
作者(Author): 周琪;
Email:
DOI:
参考文献(References):
- [1]钱学森.工程和工程科学.工程研究-跨学科视野中的工程[J]. 2010, 2(4):282-289.
- [2] Zhao X Y, Li W, Lv Z, et al. iPS cells produce viable mice through tetraploid complementation. Nature[J]. 2009,461(7260):86-88.
- [3] Li W, Shuai L, Wan H F, et al. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature[J].2012, 490(7420):407-411.
- [4] Li X, Wang J Q, Wang L Y, et al. Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos.Journal of Molecular Cell Biology[J]. 2015, 7(5):486-488.
- [5] Li Z K, Wan H F, Feng G H, et al. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Research[J]. 2016, 26(1):135-138.
- [6] Li Z K, Wang L Y, Wang L B, et al. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell[J].2018, 23(5):665-676.
- [7] Li X, Cui X L, Wang J Q, et al. Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells.Cell[J]. 2016, 164(1):279-292.
- [8] Wang Y K, Zhu W W, Wu M H, et al. Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson’s Disease. Stem Cell Reports[J].2018, 11(1):171-182.
- [9] Peng G D, Suo S B, Cui G Z, et al. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature[J]. 2019, 572(7770):528-532.
- [10] Yan P, Li Q, Wang L, et al. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell[J]. 2019, 24(3):447-461.
- [11] Ma H X, Zhai J L, Wan H F, et al. In vitro culture of cynomolgus monkey embryos beyond early gastrulation.Science[J]. 2019, 366(6467):836-844.
- [12] Gleizer S, Ben-Nissan R, Bar-On Y M, et al. Conversion of Escherichia coli to Generate All Biomass Carbon from CO2. Cell[J]. 2019, 179(6):1255-1263.